Valproic acid
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Inappropriate antidiuretic hormone secretion: case report A 22-year-old man developed inappropriate antidiuretic hormone secretion during treatment with valproic acid for idiopathic generalised tonic-clonic epilepsy. The man, who had received valproic acid 1000 mg/day for the previous 9 months, was hospitalised with a 3-day history of abdominal pain, vomiting and nausea. Laboratory investigations revealed the following levels: sodium 118 mEq/L, potassium 3.1 mEq/L, chloride 86 mEq/L, serum osmolarity 246 mosm/L, urine sodium 150 mEq/L and urine osmolarity 380 mosm/kg. He was diagnosed with inappropriate antidiuretic hormone secretion due to hyponatraemia, and low serum and high urine osmolarity levels. Valproic acid was discontinued and the man received a hypertonic saline infusion. He had immediate resolution of symptoms after hyponatraemia was corrected. Levetiracetam was initiated and he was discharged. His sodium levels were normal 3 and 6 weeks after discharge. Bavbek N, et al. Hyponatraemia associated with sodium valproate in a 22-year-old male. Nephrology Dialysis Transplantation 23: 410, No. 1, Jan 2008 801101661 Turkey
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Reactions 1 Mar 2008 No. 1191
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