Quetiapine
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Rhabdomyolysis: case report A 26-year-old man with moderate mental retardation developed rhabdomyolysis following treatment with quetiapine [therapeutic indication not clearly stated]. The man started oral quetiapine 200mg [frequency not stated] alongside a background regimen of risperidone, topiramate, clonazepam [Rivotril], flurazepam and biperiden for frequent episodes of aggressiveness. He presented 2 weeks after initiating quetiapine with a 1-week history of increased irritability, refusal to obey orders from his caregivers and abdominal pain. Physical examination was unremarkable except for self-inflicted superficial lesions (bites on his hands). Laboratory tests revealed elevated concentrations of creatine kinase and creatine kinase myocardial band (CK-MB) mass. He was diagnosed with quetiapine-induced rhabdomyolysis. Quetiapine was discontinued. Treatment with IV glucose and saline solution resulted in progressive normalisation of the man’s creatine kinase concentration. Author comment: "In accordance with Karch and Lasagna, we should consider the relation between quetiapine intake and the adverse event observed (rhabdomyolysis) as "likely" ... However, because it is not possible to rule out a drug interaction with the other drugs the patient was taking, this causal relation should be considered as "possible" in accordance with other algorithms". Velasco-Montes J, et al. Rhabdomyolysis secondary to quetiapine. Actas Espanolas 803077404 de Psiquiatria 40: 97-9, No. 2, Mar-Apr 2012 - Spain
0114-9954/10/1421-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 29 Sep 2012 No. 1421
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