SMC Complexes Methods and Protocols
This book brings together recent methods and theoretical approaches developed to dissect the activity and function of bacterial and eukaryotic Structural Maintenance of Chromosome (SMC) proteins. The protocols explore numerous subjects such as depletion s
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Anjana Badrinarayanan Editor
SMC Complexes Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
SMC Complexes Methods and Protocols
Edited by
Anjana Badrinarayanan National Centre for Biological Sciences, Tata Institute of Fundamental Research (TIFR), Bangalore, India
Editor Anjana Badrinarayanan National Centre for Biological Sciences Tata Institute of Fundamental Research (TIFR) Bangalore, India
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9519-6 ISBN 978-1-4939-9520-2 (eBook) https://doi.org/10.1007/978-1-4939-9520-2 © Springer Science+Business Media, LLC, part of Springer Nature 2019 Chapters 3, 10 and 19 are licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). For further details see license information in the chapters. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Chromosomes must be highly compacted to fit inside the limited volume of a cell. In this confined space, they must also be faithfully duplicated, segregated, and transcribed. Several studies have begun to reveal the general principles of genome organization and maintenance across domains of life and have identified and mechanistically characterized central players that mediate key steps of this process, such as the Structural Maintenance of Chromosome (SMC) proteins. SMC proteins are ubiquitous across prokaryotic and eukaryotic systems and participate in a range of
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