Squid pen chitosan nanoparticles: small size and high antibacterial activity
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Squid pen chitosan nanoparticles: small size and high antibacterial activity Nguyen Van Hoa1 · Nguyen Thi Hong Vuong2 · Nguyen Cong Minh2 · Hoang Ngoc Cuong3 · Trang Si Trung1 Received: 25 September 2020 / Revised: 10 November 2020 / Accepted: 13 November 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Chitosan nanoparticles (CSNs) have widely studied for many potential applications as a bioactive nanomaterial because of their excellent properties, such as quantum size effect, large surface area, high mobility, and high permeability. In this study, various CSNs prepared from squid pen chitosan with different molecular weight (Mw) and degree of deacetylation (DD). The lower M w and higher DD of initial chitosan used, the smaller size of CSNs obtained. Small size CSNs (about 30 nm) are formed from the initial chitosan ( Mw of 8 kDa, DD of 96%). In vitro tests, all as-prepared CSNs showed high antibacterial activity against Salmonella sp. and Staphylococcus aureus. In particular, the lowest CSNs concentration of 50 ppm, which was prepared from chitosan with a low Mw of 8 kDa and high DD of 96%, showed the highest activity. Besides, by using the similar initial chitosans, CSNs prepared from squid pens exhibit higher antibacterial activity than that one from shrimp shells. This study presents high potential applications of CSNs prepared from squid pen chitosan with small size and excellent antibacterial activity for various fields. Keywords Squid pens · Chitosan nanoparticles · Antibacterial activity · Molecular weight · Deacetylation degree
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s0028 9-020-03488-7) contains supplementary material, which is available to authorized users. * Nguyen Van Hoa [email protected] * Trang Si Trung [email protected] 1
Faculty of Food Technology, Nha Trang University, Nha Trang, Vietnam
2
Insitute for Biotechnology and Environment, Nha Trang University, Nha Trang, Vietnam
3
Faculty of Biotechnology, Binh Duong University, Thu Dau Mot, Vietnam
13
Vol.:(0123456789)
Polymer Bulletin
Introduction Chitosan is a product of the N-deacetylation reaction of chitin, which can extract from crustacean shells, squid pens, insects, and fungi [1–3]. Chitosan is nontoxic, biodegradable, biocompatible, antimicrobial, and antioxidation properties [4, 5]. Therefore, it has attracted increasing attention for many applications in the food industry, agriculture, environmental treatment, medicine, pharmacy, textiles, and cosmetics [6]. However, chitosan is a water-insoluble polymer because of its intramolecular hydrogen bondings and high molecular weight [4, 5]. So far, many efforts have been paid to improve its solubility or dispersion, such as degradation of chitosan to form low molecular chitosan or oligochitosan, conversion of chitosan into chitosan salts, modification or grafting of chitosan with hydrophilic groups, and the formation of chitosan nanoparticles (CSNs) [7–11]. Among these strategies, CSNs are
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