UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: developm
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Research Letter
UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: development of antibacterial nanofibrous hydrogel G.M. Estrada-Villegas and J.I. Del Río-De Vicente, CONACyT — Centro de Investigación en Química Aplicada, Av. Alianza Sur 204 Parque de Innovación e Investigación Tecnológica, Apodaca, Nuevo León 66629, Mexico L. Argueta-Figueroa, CONACyT — Facultad de Odontología, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca 68120, Mexico G. González-Pérez, Departamento de Ingeniería, Tecnológico Nacional de México, Instituto Tecnológico de Nuevo León, Av. Eloy Cavazos, # 2001 Colonia Tolteca, Guadalupe, Nuevo León 67170, Mexico Address all correspondence to G.M. Estrada-Villegas at [email protected] (Received 26 May 2020; accepted 21 September 2020)
Abstract UV-initiated crosslinking of electrospun poly(ethylene) oxide (PEO)/chitosan (CS) nanofibers doped with zinc oxide nanoparticles (ZnO-NPs) was performed using pentaerythritol triaclyrate (PETA) as the photoinitiator and crosslinker agent. The influence of the addition of PETA to the PEO/CS diameter and crosslinking of nanofibers was evaluated. The effect of irradiation time on the morphology and swelling properties of the crosslinked nanofibers were investigated. For ZnO-NPs, the minimum inhibitory concentrations were found at 1 mg/mL, and the minimum bactericidal concentrations at 2 mg/mL for all the strains tested. The nanofibrous hydrogel antibacterial effect was tested. This material enters the realm of fibrous hydrogels which have potential use in several applications as in the biomedical area.
Introduction Electrospinning is a technique for micro and nanofibers fabrication that is currently being explored for purposes of fabricating polymeric biomaterials. Though the technique makes it possible to work with a plethora of materials in almost any area, it has found novel possibilities in tissue engineering.[1] This technique allows for the incorporation of several nanocompounds on the surface or in the bulk of the fiber in one step. Many authors have incorporated metallic nanoparticles to obtain specific properties, such as an electric or bactericidal effect.[2] Nanoparticles are being widely explored due to the different properties that arise thanks to their small size. Among them, zinc oxide (ZnO) presents multiple properties, having good photocatalytic activity, high stability, antibacterial activity, and nontoxicity.[3] Nanogels are polymer nanoparticles with three-dimensional networks made by chemical and/or physical crosslinking of the polymer chains. Various nanogels have been designed with a focus on biomedical applications for drug-delivery systems (DDSs), regenerative medicine, and bioimaging, among others.[4] Despite the various nanogels that have been developed, the concept of fibrous nanogels in the biomedical field has not been extensively explored. Nanofibers obtained by electrospinning are currently the best way to fabricate scaffolds, wound healing patches, or DDS. However, t
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