Vascular Effects of Hydrogen Sulfide Methods and Protocols
This book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations. Alterations of vascular H2S generation/signaling may be involved in the pathog
- PDF / 6,327,591 Bytes
- 223 Pages / 504.63 x 737.01 pts Page_size
- 23 Downloads / 229 Views
Jerzy Bełtowski Editor
Vascular Effects of Hydrogen Sulfide Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Vascular Effects of Hydrogen Sulfide Methods and Protocols
Edited by
Jerzy Bełtowski Department of Pathophysiology, Medical University, Lublin, Poland
Editor Jerzy Bełtowski Department of Pathophysiology Medical University Lublin, Poland
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9527-1 ISBN 978-1-4939-9528-8 (eBook) https://doi.org/10.1007/978-1-4939-9528-8 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Hydrogen sulfide (H2S) was first identified as the endogenous mediator (“gasotransmitter”) in 1996. Since that time, a lot of studies about the role of H2S in the regulation of various physiological processes have been performed. The vascular system is one of the main H2S targets. H2S is synthesized in all parts of the vascular wall (endothelium, smooth muscle cells, periadventitial adipose tissue) and is involved in the regulation of vascular tone, although its exact effect (vasoconstriction vs. vasorelaxation) and mechanism of activity differ depending on experimental animal species and vascular preparation. Alterations of vascular H2S generation/signaling may be involved in the pathogenesis of systemic and pulmonary arterial hypertension, ischemic heart disease, ischemic stroke, preeclampsia, and erectile dysfunction; all these
Data Loading...
