Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pse
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BIOTECHNOLOGY AND INDUSTRIAL MICROBIOLOGY - REVIEW
Antibacterial and antibiofilm potential of silver nanoparticles against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains Davi de Lacerda Coriolano 1 & Jaqueline Barbosa de Souza 1 & Elias Vicente Bueno 2 & Sandrelli Meridiana de Fátima Ramos dos Santos Medeiros 1 & Iago Dillion Lima Cavalcanti 1 & Isabella Macário Ferro Cavalcanti 1,3 Received: 22 May 2020 / Accepted: 12 November 2020 # Sociedade Brasileira de Microbiologia 2020
Abstract Due to the severity of infections caused by P. aeruginosa and the limitations in treatment, it is necessary to find new therapeutic alternatives. Thus, the use of silver nanoparticles (AgNPs) is a viable alternative because of their potential actions in the combat of microorganisms, showing efficacy against Gram-positive and Gram-negative bacteria, including multidrug-resistant microorganisms (MDR). In this sense, the aim of this work was to conduct a literature review related to the antibacterial and antibiofilm activity of AgNPs against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains. The AgNPs are promising for future applications, which may match the clinical need for effective antibiotic therapy. The size of AgNPs is a crucial element to determine the therapeutic activity of nanoparticles, since smaller particles present a larger surface area of contact with the microorganism, affecting their vital functioning. AgNPs adhere to the cytoplasmic membrane and cell wall of microorganisms, causing disruption, penetrating the cell, interacting with cellular structures and biomolecules, and inducing the generation of reactive oxygen species and free radicals. Studies describe the antimicrobial activity of AgNPs at minimum inhibitory concentration (MIC) between 1 and 200 μg/mL against susceptible and MDR P. aeruginosa strains. These studies have also shown antibiofilm activity through disruption of biofilm structure, and oxidative stress, inhibiting biofilm growth at concentrations between 1 and 600 μg/mL of AgNPs. This study evidences the advance of AgNPs as an antibacterial and antibiofilm agent against Pseudomonas aeruginosa strains, demonstrating to be an extremely promising approach to the development of new antimicrobial systems. Keywords AgNPs . Antibacterial activity . Antibiofilm activity . Pseudomonas aeruginosa . Multidrug-resistant bacteria . Biofilm
Introduction
Editorial Responsibility: Luis Henrique Souza Guimaraes * Iago Dillion Lima Cavalcanti [email protected] * Isabella Macário Ferro Cavalcanti [email protected] 1
Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, PE 50670-901, Brazil
2
Nova Esperança University Hospital (HUNE), João Pessoa, PB, Brazil
3
Laboratory of Microbiology and Immunology, Academic Center of Vitória (CAV), Federal University of Pernambuco (UFPE), Vitória de Santo Antão, PE, Brazil
Bacterial infections represent one o
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