Bioconjugation Protocols Strategies and Methods
Contemporary approaches to the synthesis of chemically modified biomacromolecules (proteins, nucleic acids, lipids, and carbohydrates) not only require efficient means to control conjugation and the specific site of attachment of the conjugated moiety but
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Bioconjugation Protocols Strategies and Methods
Second Edition
Edited by
Sonny S. Mark Pacific Biosciences, Menlo Park, CA, USA
Editor Sonny S. Mark, Ph.D. Pacific Biosciences Menlo Park CA, USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-150-5 e-ISBN 978-1-61779-151-2 DOI 10.1007/978-1-61779-151-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011928240 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of nformation storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface I am very pleased to present the second edition of Bioconjugation Protocols: Strategies and Methods, part of the excellent Methods in Molecular Biology™ book series. This current volume builds on the outstanding first edition originally conceived and developed by Prof. Christof M. Niemeyer at Technische Universität Dortmund (Germany). The first edition of this book aimed to address the deficiencies of many of the conventional approaches to the synthesis of chemically modified biomolecular conjugates that lack efficient means to control the stoichiometry of conjugation, as well as the specific site of attachment of the conjugated moiety. In keeping with that aim, this updated and expanded second edition of Bioconjugation Protocols further explores newer approaches that overcome the limitations of classical synthetic methods. In addition, a number of protocols collected in this new volume clearly reflect how insightful techniques and innovative approaches in bioconjugate chemistry can be derived from the seamless interplay between the fields of organic synthesis, surface biotechnology, nanobioscience, and materials science and engineering. It is thus my sincere hope
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