Biosynthesis of TiO 2 Nanoparticles Using Edible Mushroom ( Pleurotus djamor ) Extract: Mosquito Larvicidal, Histopathol
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ORIGINAL PAPER
Biosynthesis of TiO2 Nanoparticles Using Edible Mushroom (Pleurotus djamor) Extract: Mosquito Larvicidal, Histopathological, Antibacterial and Anticancer Effect Kumar Manimaran1 • Subban Murugesan1 • Chinnasamy Ragavendran2 • Govindasamy Balasubramani3 Devarajan Natarajan2 • Abirami Ganesan4 • Palaniappan Seedevi5
•
Received: 30 March 2020 / Accepted: 8 September 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The titanium dioxide nanoparticles (TiO2NPs) were synthesized by the aqueous extract from P. djamor. The UV–Vis spectrum of TiO2NPs showed maximum absorption at 345 nm and the XRD pattern reflects peaks at 2h value of 27.51, 36.16, 41.31, 54.37, 56.68, 62.80 and 69.04 can be indexed to the (110), (101), (111), (211), (220), (204) and (301) were confirm the presence of TiO2NPs. The FT-IR spectrum of TiO2NPs showed a peak at 3432, 1631, 1400, 1109, and 619 cm-1. The SEM and HRTEM analysis revealed the spherical shape size and EDAX pattern confirmed the purity of TiO2NPs. The particle size of TiO2NPs found to be 31 nm and the zeta potential showed 16.4mV. Antibacterial activity TiO2NPs recorded the highest zone of inhibition 33 ± 0.2 mm, 32 ± 0.4 mm and 32 ± 0.1 mm against P. fluorescens, S. aureus and C. diphtheriae. Further, the anticancer activity of TiO2NPs showed 9.08–64.71% at 6.25–100 lg/ml concentration against A549 cancer cells. The larvicidal activities of TiO2 NPs on IVth instar larvae of Ae. aegypti and Cx quinquefasciatus results showed LC50 (5.88 and 4.84 mg/l) and LC90 (22.80 and 19.33 mg/l) in better effect. The multi biological activity of TiO2NPs was utilized in future pharmacological application. Graphic Abstract
& Subban Murugesan [email protected] 1
Edible and Medicinal Mushroom Laboratory, Department of Botany, School of Life Sciences, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636 011, India
2
Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Periyar Palkalai Nagar, Salem, Tamil Nadu 636 011, India
3
School of Pharmaceutical Science and Technology, Health Science Platform, Tianjin University, Tianjin 300072, China
4
Department of Food Science, School of Applied Sciences, College of Engineering, Science and Technology, Fiji National University, Suva 7222, Fiji Islands
5
Department of Environmental Science, Periyar University, Salem, Tamil Nadu 636011, India
123
K. Manimaran et al.
Keywords TiO2 NPs Pleurotus djamor Mosquito larvicidal Antibacterial Anticancer effect
Introduction Nanotechnology plays a crucial role in modern science and possesses several applications in medical fields such as imaging techniques, targeted drug delivery, and molecular diagnosis [1]. The sizes of nanoparticles are accomplished in the range of 1-100 nm [2, 3]. Nanomaterials have been attracted by the researchers due to their wide applications in day-to-day life [4]. Most of the biological mediated synthesis is
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