CD95 Methods and Protocols
This volume provides the most commonly used methods and protocols to study the apoptotic and non-apoptotic roles of CD95. Chapters explore molecular, biochemical, cellular methods and animal models to in order to better understand the biological func
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Patrick Legembre Editor
CD95 Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
CD95 Methods and Protocols
Edited by
Patrick Legembre ER440-OSS, Label INSERM, Universite de Rennes CLCC Eugene Marquis, Rennes, France
Editor Patrick Legembre ER440-OSS, Label INSERM Universite de Rennes CLCC Eugene Marquis Rennes, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6778-0 ISBN 978-1-4939-6780-3 (eBook) DOI 10.1007/978-1-4939-6780-3 Library of Congress Control Number: 2016963637 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Apoptosis consists of two main signaling pathways distinguished by the origins of the signals. While the interaction of the apoptotic ligands to their respective death receptors (DRs) at the cell surface activates the extrinsic signaling pathway, the intrinsic signaling pathway is provoked by accumulation of DNA damages, oncogene overexpressions, deregulation of mitochondrial functions, reticulum endoplasmic stresses, and/or viral infections. These pathways are interconnected, and both converge on activation of a family of cysteine proteases designated the caspases. The apoptotic role of the mitochondrion is associated with a reduction in its transmembrane potential and the loss of its extracellular membrane integrity, leading to the release of various apoptogenic factors into the cytosol. DRs (TNFR1, CD95, DR3, DR4, DR5, and DR6) belong to the TNF receptor (TNF- R) superfamily. These type I transmembrane proteins share common featur
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