Cell Cycle Checkpoints Methods and Protocols
Cell cycle checkpoints control the fidelity and orderly progression of eukaryotic cell division. By controlling the orderly progression of critical cell cycle events such as DNA replication and chromosome segregation and ensuring proper repair of damaged
- PDF / 6,128,152 Bytes
- 303 Pages / 504 x 720 pts Page_size
- 66 Downloads / 181 Views
IN
M OLECULAR B IOLOGY TM
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Cell Cycle Checkpoints Methods and Protocols
Edited by
Willis X. Li Department of Medicine, University of California, San Diego, La Jolla, CA, USA
Editor Willis X. Li Department of Medicine University of California, San Diego La Jolla, CA 92093-0063, USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-272-4 e-ISBN 978-1-61779-273-1 DOI 10.1007/978-1-61779-273-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011935428 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Cell cycle checkpoints control the fidelity and orderly progression of eukaryotic cell division. These checkpoints prevent progression into the next phase of the cell cycle until the processes at the current phase have been properly completed. The most studied cell cycle checkpoints act at transition points, such as from G1 to S, G2 to M, or the metaphase to anaphase transition. Genotoxic stresses from byproducts of cellular metabolism or environmental sources can also activate cell cycle checkpoints, halting cell cycle progression until the damages are repaired. By controlling the orderly progression of critical cell cycle events such as DNA replication and chromosome segregation, and ensuring proper repair of damaged DNA, cell cycle checkpoints function to ensure genome integrity. Cell cycle checkpoint pathways consist of sensors that detect DNA damage or incomplete cell cycle processes, signal transducers that halt cell cycle progression, and effectors that execute damage repair or a commitment to apoptosis, if the damage cannot be repaired. Research in the past decade or so has elucidated many of the molecular mechanisms involved in various aspects of cell cycle checkpoints. Mechanisms of checkpoint control are not only the focus of investigators interested in cell cycle regulation, but are also of interest to researchers studying cancer development. It is becoming increasingly clear that loss of cell cycle checkpoints, which lead
Data Loading...
