Cohesin and Condensin Methods and Protocols
The volume provides comprehensive, state-of-the-art experimental techniques that are now available to dissect the molecular mechanisms of regulation and function of cohesin and the related factor condensin in vitro and in vivo across different model organ
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Kyoko Yokomori Katsuhiko Shirahige Editors
Cohesin and Condensin Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cohesin and Condensin Methods and Protocols
Edited by
Kyoko Yokomori Department of Biological Chemistry, School of Medicine, University of California—Irvine, Irvine, CA, USA
Katsuhiko Shirahige Laboratory of Genome Structure and Function, Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
Editors Kyoko Yokomori Department of Biological Chemistry School of Medicine University of California— Irvine Irvine, CA, USA
Katsuhiko Shirahige Laboratory of Genome Structure and Function Research Center for Epigenetic Disease Institute of Molecular and Cellular Biosciences The University of Tokyo Tokyo, Japan
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6543-4 ISBN 978-1-4939-6545-8 (eBook) DOI 10.1007/978-1-4939-6545-8 Library of Congress Control Number: 2016954307 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A
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Preface There is a rapidly expanding body of literature demonstrating that cohesin, originally characterized as an essential factor mediating mitotic sister chromatid cohesion, is also a chromatin organizer important for gene regulation and DNA repair. Furthermore, cohesin is also critical for meiotic chromosome regulation. Cohesin plays a critical role in cellular differentiation and development. Abnormalities in cohesin functions are now directly linked to a collection o
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