Collagen Methods and Protocols
This detailed volume compiles state-of-the-art protocols that will serve as recipes for scientists researching collagen, an abundant protein with great importance to health and disease, as well as in applications like food, cosmetics, pharmaceuticals, cos
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Irit Sagi · Nikolaos A. Afratis Editors
Collagen Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Collagen Methods and Protocols
Edited by
Irit Sagi and Nikolaos A. Afratis Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
Editors Irit Sagi Department of Biological Regulation Weizmann Institute of Science Rehovot, Israel
Nikolaos A. Afratis Department of Biological Regulation Weizmann Institute of Science Rehovot, Israel
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9094-8 ISBN 978-1-4939-9095-5 (eBook) https://doi.org/10.1007/978-1-4939-9095-5 Library of Congress Control Number: 2019930144 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Collagen is the most abundant protein in mammals, making up about 25% of the wholebody protein content. Collagen is involved in many physiological and pathological situations. Specifically, collagen has been shown to be involved either directly or indirectly in the promotion of cell adhesion and differentiation, cell functions that are related to the control of embryonic development and regeneration. However, the uncontrolled synthesis and accumulation of collagen from fibroblasts lead to pathological conditions in fibrotic-related diseases and tumorigenesis. Collagen is the main structural protein in extracellular matrix and connective tissue. The basic fundamental s
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