Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated P
- PDF / 2,212,871 Bytes
- 14 Pages / 595.276 x 790.866 pts Page_size
- 87 Downloads / 229 Views
ARTICLE
Cite as Nano-Micro Lett. (2019) 11:36 Received: 25 February 2019 Accepted: 6 April 2019 © The Author(s) 2019
https://doi.org/10.1007/s40820-019-0266-0
Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage‑Mediated Photothermal Therapy Sang Bong Lee1, Jae‑Eon Lee2, Sung Jin Cho1,3, Jungwook Chin1, Sang Kyoon Kim7, In‑Kyu Lee3,5, Sang‑Woo Lee3,4, Jaetae Lee4,6, Yong Hyun Jeon3,7 * Sang Bong Lee and Jae-Eon Lee contributed equally to this study. * Yong Hyun Jeon, [email protected] New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea
1 2
3
4
6 7 5
Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, South Korea Leading‑Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 702‑210, South Korea Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu 702‑210, South Korea Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 700‑721, South Korea Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 360‑4, South Korea Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 360‑4, South Korea
HIGHLIGHTS • Crushed gold shell radionuclide nanoballs (124I-Au@AuCBs) were fabricated as unique photothermal therapeutics and nuclear medicine imaging nanoplatforms. • Macrophage-mediated delivery of 124I-Au@AuCBs and their potential photothermal therapy applications were demonstrated in mice with colon cancer.
ABSTRACT Plasmonic nanostructure-mediated photothermal therapy (PTT) has effective delivery to tumor lesions are currently being developed. This study aimed
platform. 124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotox‑ icity. After the administration of
124
I-Au@AuCB-labeled macrophages to colon
tumors, intensive signals were observed at tumor lesions, and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects. The results indicate the
CT
°C NIR laser 808 nm
to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells (124I-Au@AuCBs) as a theranostic nano‑
Infrared thermal imaging
Photo graphy
52.2 °C
Tumor
6 W cm−2 5 min
T T
124I-Au@AuCBs
Labeled macrophage Macrophage
PTT Before T
NIR laser 808 nm
Tumor
After T
6 W cm−2 5 min
considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and
T: tumor
1.0 ×1010
proven to be a promising approach for cancer treatment, and new approaches for its
124I-Au@AuCBs
0.0
the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases. KEYWORDS Photothermal therapy; Radionuclide crushed gold shell nanoballs; Macrophage-mediated delivery
Data Loading...
