Histones Methods and Protocols
This volume provides a comprehensive list of protocols for molecular biologists, biochemists and geneticists. Chapters cover protocols that further the study into protein complexes that modify chromatin either by adding or removing post-translational modi
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Benoit Guillemette Luc Gaudreau Editors
Histones Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Histones Methods and Protocols
Edited by
Benoit Guillemette Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada
Luc Gaudreau Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada
Editors Benoit Guillemette Department of Biology Université de Sherbrooke Sherbrooke, QC, Canada
Luc Gaudreau Department of Biology Université de Sherbrooke Sherbrooke, QC, Canada
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6628-8 ISBN 978-1-4939-6630-1 (eBook) DOI 10.1007/978-1-4939-6630-1 Library of Congress Control Number: 2016958302 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Histones are the fundamental building blocks upon which eukaryotic cells rely to compact and organize their DNA in the nucleus. The essential nature of histones for the composition of chromatin has been known for many years, but we are merely beginning to understand how histones contribute in organizing the genome in the three dimensions of the nucleus and impact in regulating gene expression, DNA replication, and repair. Histone research has greatly expanded in the last 15 years, and an increasing number of laboratories have taken interest in studying them. This book aims at providing a comprehensive list of protocols for molecular biologists, biochemists, and geneticists who wish to study the many aspects of histone biology both in vivo and in vitro: from the
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