mRNA Processing Methods and Protocols
This detailed volume assembles a number of the most commonly used and state-of-the-art methodologies in the revolutionary field of mRNA processing in order to aid researchers in choosing the best method for their specific problems. Given that the vast maj
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Yongsheng Shi Editor
mRNA Processing Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Herts., United Kingdom
For further volumes: http://www.springer.com/series/7651
mRNA Processing Methods and Protocols
Editor
Yongsheng Shi Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA, USA
Editor Yongsheng Shi Department of Microbiology and Molecular Genetics School of Medicine University of California Irvine, CA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7203-6 ISBN 978-1-4939-7204-3 (eBook) DOI 10.1007/978-1-4939-7204-3 Library of Congress Control Number: 2017946167 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The year 2017 is the 40th anniversary of the landmark discovery of splicing by the laboratories of Richard J. Roberts and Phillip A. Sharp. At the time, it was unclear whether splicing was a rare event or a common phenomenon. With the completion of the Human Genome Project, we now know that splicing is a nearly universal mechanism for human mRNA maturation. More importantly, the great majority of human genes produce multiple mRNA isoforms through alternative mRNA processing, including alternative splicing and alternative polyadenylation. These alternative mRNA processing events are highly regulated in a tissue- and/or developmental stage-dependent manner. Aberrant regulation of mRNA processing has been causally linked to or implicated in many human diseas
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