Antigen Processing Methods and Protocols
The second edition volume expands on the previous edition with new and updated chapters on the latest methods used for studying presentation of antigenic peptides produced in the standard processing pathways for MHC class I and II molecules. The new chapt
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Peter van Endert Editor
Antigen Processing Methods and Protocols Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Antigen Processing Methods and Protocols Second Edition
Edited by
Peter van Endert INSERM U1151, Université Paris Descartes, Hopital Necker-Enfants Malades, Paris, France
Editor Peter van Endert INSERM U1151, Universite´ Paris Descartes Hopital Necker-Enfants Malades Paris, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9449-6 ISBN 978-1-4939-9450-2 (eBook) https://doi.org/10.1007/978-1-4939-9450-2 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Antigen processing, an ensemble of intracellular events involved in producing peptideloaded major histocompatibility (MHC) molecules for display at the cell surface, is a fundamental prerequisite for adaptive cellular immune responses. Scientists have now been studying antigen processing for more than 30 years, since the initial recognition that short peptide fragments of antigenic proteins associate noncovalently with MHC molecules. It is therefore not surprising that the key steps of antigen processing—proteolytic antigen degradation, peptide and MHC trafficking, chaperone-mediated formation of pMHC complexes—are now understood in great detail. The recent recognition that efficient processing and presentation of tumor antigens is a key variable determining the success of recent cancer th
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