Myelin Methods and Protocols
This volume collects research methodologies for both basic and translational studies of myelin authored by experts in the field. Chapters in this book are divided into three parts: Part One focuses on visualizing myelin and studying it on a biochemical le
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Ashwin Woodhoo Editor
Myelin Methods and Protocols
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Myelin Methods and Protocols
Edited by
Ashwin Woodhoo Nerve Disorders Laboratory, CIC bioGUNE, Derio, Vizcaya, Spain IKERBASQUE, Basque Foundation for Science, Bilbao, Vizcaya, Spain
Editor Ashwin Woodhoo Nerve Disorders Laboratory CIC bioGUNE Derio, Vizcaya, Spain IKERBASQUE Basque Foundation for Science Bilbao, Vizcaya, Spain
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7861-8 ISBN 978-1-4939-7862-5 (eBook) https://doi.org/10.1007/978-1-4939-7862-5 Library of Congress Control Number: 2018946618 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Myelination of axons is essential for the rapid saltatory conduction of action potentials. The ensheathment of axons is carried by specialized glial cells, oligodendrocytes in the c entral nervous system and Schwann cells in the peripheral nervous system, which elaborate the multilayered tightly compacted myelin sheath around axons as an extension of their plasma membrane. This evolutionary adaptation is a key requirement for the motor, s ensory, and cognitive functions of the vertebrate nervous system, as emphasized by the frequent neurological disorders caused by malformation or destruction of the myelin sheath, including multiple sclerosis and inherited leukodystrophi
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