Neuroproteomics Methods and Protocols
With the development of polypeptide ionization processes for mass spectrometry and the rapid processing of large-scale datasets with bioinformatics, researchers now have the tools necessary to propel neuroproteomics research to new levels. In Neuroproteom
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Neuroproteomics Methods and Protocols
Edited by
Andrew K. Ottens* and Kevin K.W. Wang† *Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA † McKnight Brain Institute of the University of Florida, Gainesville, FL, USA Banyan Biomakers, Inc., Alachua, FL, USA
Editors Andrew K. Ottens Department of Anatomy and Neurobiology Virginia Commonwealth University Richmond, VA USA
Kevin K.W. Wang McKnight Brain Institute of the University of Florida, Gainesville, FL, USA Banyan Biomakers, Inc., Alachua, FL, USA
ISBN 978-1-934115-84-8 e-ISBN 978-1-59745-562-6 ISSN 1064-3745 e-ISSN 1940-6029 DOI 10.1007/978-1-59745-562-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009927905 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013 USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface Neuroproteomics: Methods and Protocols presents experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. The target audience includes clinical or basic scientists who look to apply proteomics to the neurosciences. Often researchers hear of proteomics without an adequate explanation of the methodology and inherent limitations. This volume conveys where proteomic methodology is in its application to CNS research and what results can be expected. We also address clinical translation of neuroproteomics, specifically in the area of biomarker research. The inception of neuroproteomics capitalized on rapid progress in large-molecule mass spectrometry over the last decade. Two seminal advances have spurred research – development
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