Pain Research Methods and Protocols
The advancements of medical technology, improvements in medical care, and increased patients’ life span make pain research and related drug development high priorities for both the research community and pharmaceutical companies. Rapid development of basi
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IN
MOLECULAR BIOLOGY™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Pain Research Methods and Protocols Second Edition Edited by
Z. David Luo Department of Anesthesiology & Perioperative Care, School of Medicine, University of California Irvine, Irvine, CA, USA; Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, CA, USA
Editor Z. David Luo Department of Anesthesiology & Perioperative Care School of Medicine University of California Irvine Irvine, CA, USA and Department of Pharmacology School of Medicine University of California Irvine Irvine, CA, USA
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-560-2 e-ISBN 978-1-61779-561-9 DOI 10.1007/978-1-61779-561-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2012930385 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Since the first volume of this book was published in 2004, pain research has continued its rapid growth. This is primarily driven by the urgent need for better pain medications in health care. The advancements of medical technology, improvements in medical care, and increased patients’ life span make pain research and related drug development high priorities for both the research community and pharmaceutical companies. Rapid development of basic science research tools, such as techniques of fluorometric labeling, genomic and proteomic high-throughput screening, and genetically modified animals, promotes the swift acceleration of pain research to a stage allowing integrated investigations of pain processing mechanisms at the single cell and/or molecule level, and in a spatially and temporally controlled manner. Using multidisciplinary approaches, we can dissect the complicity of the sensory circuits connecting peripheral stimulation to maladaptive changes in the sensory pathways as well as pain perceptions at the central nervous system. While similar pain syndromes from different etiologies may have similar behavioral endpoints, it is now believed that they are derived from distinct maladaptive changes in the se
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