Polyamines Methods and Protocols
Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocol
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Polyamines Methods and Protocols Edited by
Anthony E. Pegg Department of Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, USA
Robert A. Casero, Jr. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Editors Anthony E. Pegg, Ph.D. College of Medicine Milton S. Hershey Medical Center Pennsylvania State University University Drive 500 Hershey, PA 17033-0850, USA [email protected]
Robert A. Casero, Jr., Ph.D. School of Medicine Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Orleans St. 1650 Baltimore, MD 21231, USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-033-1 e-ISBN 978-1-61779-034-8 DOI 10.1007/978-1-61779-034-8 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011921314 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Polyamines are ubiquitous cellular components that perform multiple functions and are essential for normal growth and development. Polyamine biosynthesis and the regulation of polyamine levels, which are closely linked to cell growth, have been the subject of many studies over the past 40 years. A volume of this series (Vol. 79, Polyamine Protocols) was published in 1998 and described some methods for assays of biosynthetic and catabolic enzymes, measurement of polyamine levels, and transport measurements. In the last decade, there have been important new findings in the polyamine field and a variety of new experimental systems have become available. These include studies with animal models and human patients, which indicate that polyamines play a critical role in normal development and in the development of neoplasia. Therapeutic roles for polyamine inhibitors and analogs have been established and more are under investigation. Polyamine metabolism is now recognized as a significant source of oxidative damage. Polyamines
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