Cancer Chemoprevention Methods and Protocols
This volume presents state of the art of methods that can be useful for both basic and translational researchers to conduct chemoprevention preclinical studies. Written in the highly successful Methods in Molecular Biology series format, chapters include
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Sabrina Strano Editor
Cancer Chemoprevention Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cancer Chemoprevention Methods and Protocols
Edited by
Sabrina Strano Molecular Cancer Chemoprevention Unit, Molecular Medicine Department, Regina Elena National Cancer Institute, Rome, Italy Department of Oncology, Juravinski Cancer Center-McMaster University Hamilton, Hamilton, ON L8V 5C2, ON, Canada
Editor Sabrina Strano Molecular Cancer Chemoprevention Unit Molecular Medicine Department Regina Elena National Cancer Institute Rome, Italy Department of Oncology Juravinski Cancer Center-McMaster University Hamilton Hamilton, Ontario, Canada
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3190-3 ISBN 978-1-4939-3191-0 (eBook) DOI 10.1007/978-1-4939-3191-0 Library of Congress Control Number: 2015957808 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Despite the advent of personalized therapies, cancer still remains a leading cause of death worldwide. The number of cancer cases is rising yearly and is expected to double in the next 20 years. The largest increase of new cases will occur mainly in lower income countries, where the access to cancer care is still inadequate. Thus, there is a strong and urgent need of additional and complementary therapies. The increasing healthcare costs of novel anticancer therapeutic agents and their toxic side effects in high-income countries pave the way for cancer chemoprevention strategies. Natural compounds and dietary supplement phytochemi
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