Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring

DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals.  Such isolates can be exploited in the early detection of clin

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Peter B. Gahan Editor

Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring An Introduction

Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring

Advances in Predictive, Preventive and Personalised Medicine Volume 5 Series Editor: Olga Golubnitschaja Managing Editor: Kristina Yeghiazaryan

For further volumes: http://www.springer.com/series/10051

Peter B. Gahan Editor

Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring An Introduction

Editor Peter B. Gahan Anatomy & Human Sciences King’s College London London United Kingdom

ISSN 2211-3495 ISSN 2211-3509 (electronic) ISBN 978-94-017-9167-0 ISBN 978-94-017-9168-7 (eBook) DOI 10.1007/978-94-017-9168-7 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2014954083 © Springer Science+Business Media Dordrecht 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

TO MAURICE STROUN who overcame scientific and political resistance to lay the foundations leading to the current studies on circulating nucleic acids.

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What This Book Series Is About…

Current Healthcare: What Is Behind the Issue? For many acute and chronic disorders, the current healthcare outcomes are considered