CPAP therapy reduces oxidative stress in patients with glaucoma and OSAS and improves the visual field
- PDF / 181,674 Bytes
- 3 Pages / 595.276 x 790.866 pts Page_size
- 38 Downloads / 239 Views
LETTER TO THE EDITOR
CPAP therapy reduces oxidative stress in patients with glaucoma and OSAS and improves the visual field Noriko Himori 1 & Hiromasa Ogawa 2 & Masakazu Ichinose 2 & Toru Nakazawa 1,3,4,5,6 Received: 17 June 2019 / Revised: 30 July 2019 / Accepted: 13 September 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2019
Keywords Obstructive sleep apnea syndrome . Glaucoma . Oxidative stress . Continuous positive airway pressure . Perimetry
Dear Editor, Obstructive sleep apnea syndrome (OSAS)-induced intermittent hypoxia is considered to contribute to glaucoma [1]. We previously found that patients with both open-angle glaucoma (OAG) and OSAS had higher levels of oxidative stress, and that the visual field deteriorated more quickly in these patients than in OAG patients without OSAS [2]. Here, we measured oxidative stress and glaucoma progression before and after the start of continuous positive airway pressure (CPAP) therapy in OAG patients with OSAS. Full-night comprehensive polysomnography, including the measurement of apnea hypopnea index (AHI), was carried out for all patients before and after the initiation of CPAP therapy. A free radical analyzer (Wismerll Co. Ltd., Tokyo, Japan) was used to measure diacron reactive oxygen metabolites (dROMs) and biological antioxidant potential (BAP). dROMs represent the total oxidant capacity of a sample, while BAP measures the ability of samples to reduce ions from ferric to ferrous. Oxidative stress and antioxidant capacity can be
* Toru Nakazawa [email protected] 1
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho Aoba-ku, Sendai Miyagi 980-8574, Japan
2
Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
3
Collaborative Program for Ophthalmic Drug Discovery, Tohoku University Graduate School of Medicine, Sendai, Japan
4
Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Japan
5
Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan
6
Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
easily measured in an outpatient setting with, respectively, dROMs and BAP, both obtained from serum samples. We have previously reported that these parameters are related to glaucoma [2, 3], and the current study therefore represents an extension of previous findings and methods. Mean deviation (MD) was measured with HFA (Carl Zeiss Meditec, Dublin, CA) using the SITA standard 24-2 program. If both eyes met the inclusion criteria, the eye with the worse MD was selected for the statistical analysis. Only reliable data were used (false negatives < 15%, false positives < 15%, and fixation loss < 20%). MD slope, measured with HfaFiles software (Beeline Co. Ltd., Tokyo, Japan), was used to determine progression. Findings before and after CPAP therapy were compared with the Wilcoxon signed-rank test. Thi
Data Loading...
