Current Topics in Microbiology and Immunology Ergebnisse der Mikrobi
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64 Edited by W. Arber, Basle . R. Haas, Freiburg . W. Henle, Philadelphia . P. H. Hofschneider, Martinsried . J. H. Humphrey, London· N.K.Jerne,Basle. P.KoldovskY, Philadelphia H.Koprowski, Philadelphia. O. Maalee, Copenhagen. R. Rott, Giejen· H. G. Schweiger, Wilhelmshaven . M. Sela, Rehovol . L. Syrucek, Prague· P. K. Vogl, Seattle E. Wecker, Wiirzburg
With 16 Figures
Springer-Verlag Berlin· Heidelberg· New York 1974
ISBN-13: 978-3-642-65850-1 DOl: 10.1007/978-3-642-65848-8
e-ISBN-13: 978-3-642-65848-8
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re·use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. © by Springer·Verlag Berlin· Heidelberg 1974. Library of Congress Catalog Card Number 74-3541. Softcover reprint of the hardcover 1st edition 1974 The use of regIStered names, trademarks, etc. in this publicatIon does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulatIons and therefore free for general use. Universitatsdruckerei H. Sturtz AG, Wurzburg
Table of Contents HAWTHORNE, D. c., and LEUPOLD, U., Suppressor Mutations in Yeast. With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1
MIYAKE, A., Cell Interaction in Conjugation of Ciliates. With 14 Figures
49
TALAL, N., and STEINBERG, A. D., The Pathogenesis of Autoimmunity in New Zealand Black Mice . . . . . . . . . . . . . . . . . . . . . ,
79
MOORE, R. L., Nucleic Acid Reassociation as a Guide to Genetic Relatedness among Bacteria 105 Author Index Subject Index
129
,
.
141
Suppressors in Yeast DONALD
C.
HAWTHORNE
and
DRS LEUPOLD!
With 2 Figures Table of Contents 1. Introduction . . . . . . . 2. The Characterization of the Super-suppressible Mutants in Saccharomyces cerevisiae and Schizosaccharomyces pombe . . . . . . . . . 3. The Identification of the Nonsense Codons in Saccharomyces. a) A Direct Demonstration of UAA and UAG Mutants. . . b) The Isolation of UAG and UGA Nonsense Mutants . . . 4. The Isolation and Classification of the Super-suppressors in Saccharomyces 5. Mapping the Suppressors in Saccharomyces . . . . . . . . . . . . . . . . 6. The Relationship of the Nonsense Mutants and Super-suppressors in Schizosaccharomyces. . . . . . . . . . . . . . . . . . . 7. The Nature of the Codon Specific Suppressors in Yeast. . . . . . . . . . . a) Mutation Studies with Saccharomyces . . . . . . . . . . . . . . . . . b) The Fine Structure Mapping of Nonsense Suppressors in Schizosaccharomyces 8. Omnipotent Suppressors . . . 9. Missense Suppressors. . . . . 10. Adverse Effects of Suppressors 11. Modifiers of Suppressors 12. Concluding Remarks . 13. Appendix . . . . . . . a)
