Effect of Heavy Metal Contamination in the Environment on Antioxidant Function in Wumeng Semi-fine Wool Sheep in Southwe
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Effect of Heavy Metal Contamination in the Environment on Antioxidant Function in Wumeng Semi-fine Wool Sheep in Southwest China Xiaoyun Shen 1,2,3
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Xiaoying Min 2
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Shihao Zhang 2
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Chunjie Song 1
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Kangning Xiong 2
Received: 14 September 2019 / Accepted: 11 February 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Many environmental accidents have led to worldwide heavy metal pollution, raising concern about heavy metal toxicity in Southwest China. To study the effects of Cd and Pb in the environment on antioxidant function in Wumeng semi-fine wool sheep, contents of Cu, Zn, Mn, Mo, Fe, Se, Cd, and Pb were measured in irrigation water, soil, herbage, and animal tissues. Hematological and biochemical parameters were also determined. The concentrations of Cu, Zn, Cd, and Pb in affected samples of irrigation water, soil, herbage, and tissues were significantly higher than those in the control (P < 0.01). There was no significant difference in other element contents between affected pastures and control areas. The occurrence of anemia affected Wumeng semi-fine wool sheep. The activities of SOD, CAT, and GSH-Px in affected animals were significantly decreased than those in the control (P < 0.01). Content of MDA in serum in affected animals was significantly increased than that in control (P < 0.01). Serum T-AOC in affected animal was significantly lower than that in control (P < 0.01). Consequently, it is suggested that heavy metal contamination in natural habitat caused serious harm to antioxidant function in Wumeng semi-fine wool sheep. Keywords Antioxidant function . Heavy metals . Reactive oxygen species . Wumeng semi-fine wool sheep . Natural habitat
Introduction A lot of environmental accidents have led to worldwide heavy metal pollution, raising concern about heavy metal toxicity in the Yunnan-Guizhou Plateau of China [1]. We have studied the effect of environmental heavy metal on antioxidant function in animals. The antioxidant system of animals is the defense system against free radical damage [2]. Its function is to eliminate excessive free radicals and block the chain reaction of lipid peroxides, thereby preventing the accumulation of malondialdehyde (MDA) in the body [3, 4]. The main
manifestations are cell membrane degeneration, protein damage, DNA mutation, and so on, which eventually lead to various diseases, even aging and death of organisms [5, 6]. The activity of antioxidant enzymes is closely related to heavy metal content in blood. Too low or too high contents of heavy metal in the blood will cause the activity of antioxidant enzymes to decrease [7, 8]. Therefore, processes underlying antioxidant responses to heavy metal contaminants must be clearly understood. The Yunnan-Guizhou Plateau is located in Southwest China, and it is an important pastureland for native sheep
Xiaoyun Shen and Xiaoying Min contributed equally to this work. * Kangning Xiong [email protected]
Chunjie Song [email protected]
Xiaoyun Shen [email protected]
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School of Life
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