Gastric cancer in young patients: a separate entity with aggressive features and poor prognosis
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ORIGINAL ARTICLE – CLINICAL ONCOLOGY
Gastric cancer in young patients: a separate entity with aggressive features and poor prognosis Lyujia Cheng1,2 · Songyao Chen1,2 · Wenhui Wu1 · Zi Chong Kuo1 · Zhewei Wei2 · Sijun Meng1 · Chuangqi Chen2 · Changhua Zhang1 · Yulong He1,2 Received: 25 April 2020 / Accepted: 18 May 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To investigate the clinicopathological features and survival outcomes between young and old patients with gastric cancer (GC), and further determine the role of young age in the prognosis of GC. Methods Patients with stage I–III gastric adenocarcinomas undergoing curative surgery were enrolled, divided into young (aged 18–49 years, YG), middle-aged (50–59 years, MG), and old (≥ 60 years, OG) groups. Exclusion criteria were neoadjuvant therapy and history of malignant tumors. Clinicopathological features, overall survival (OS), disease-free survival (DFS), and recurrence patterns were compared among three groups. Results 1131 patients were finally included, with 270, 314, and 547 cases in the YG, MG, and OG, respectively. Compared to others, YG had higher proportion of female, middle-third gastric cancer, poor differentiation, N3b stage, and adjuvant chemotherapy. YG demonstrated poorer 5-year OS than MG (62.4% vs. 70.8%, P = 0.019), but better than OG (62.4% vs. 58.7%, P = 0.031). YG also suffered inferior 5-year DFS (75.2% vs. 82.8%, P = 0.040) compared with MG, and higher incidence of peritoneal recurrence than MG (15.1% vs. 5.2%, P
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