Ovicidal and toxicological effect of hydroalcoholic extracts of Euphorbia milli var splendens, Synadenium carinatum Bois
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ORIGINAL ARTICLE
Ovicidal and toxicological effect of hydroalcoholic extracts of Euphorbia milli var splendens, Synadenium carinatum Boiss and Tagetes minuta L. against Ancylostoma spp.: In vitro study Matheus Diniz Gonc¸alves Coeˆlho1,2 • Lucas Tobias Rodrigues Maciel1 • Thaı´s de Fa´tima Kieko Ozaki1 • Maria Eduarda Godoi Silva1 • Lilian Saito Ormachea Bozo1 • Yumi Ando Consoli1 • Fernanda Bueno Sant’Anna Pereira-Maciel1 • Gokithi Akisue3 • Francine Alves da Silva-Coeˆlho4 Received: 10 July 2020 / Accepted: 27 October 2020 Ó Indian Society for Parasitology 2020
Abstract Nematodes of the Ancylostomidae family consist of important parasitic species. The control of such parasitosis represents an important challenge, given the constant high rate of reinfection of some hosts, among which the domestic dog, as well as the high environmental contamination. Another factor that can have a negative influence is the toxicity of the chemicals used for environmental decontamination, highlighting the need to design research to identify new control strategies for this parasitosis, among which the use of plant extracts. Thus, the objective of this research was to evaluate the toxicity and ovicidal activity of hydroalcoholic extracts obtained by percolation of three plants: Tagetes minuta L., Euphorbia milli var splendens (Bojer ex Hook.) Ursch & Leandri and Synadenium carinatum Boiss, against Ancylostoma spp. In addition, these extracts were tested at different concentrations for toxicity against Artemia salina L. and Allium cepa L. It was observed that the hydroalcoholic extract of all plant species evaluated induced moderate ovicide activity at all the tested concentration, with emphasis on E. milii, which was the only plant species that presented
& Matheus Diniz Gonc¸alves Coeˆlho [email protected] 1
Centro Universita´rio FUNVIC, Pindamonhangaba, Sa˜o Paulo, Brazil
2
Laborato´rio de Parasitologia e Malacologia, Centro Universita´rio FUNVIC, Pindamonhangaba, Sa˜o Paulo, Brazil
3
Laborato´rio de Farmacognosia e Plantas Medicinais, Centro Universita´rio FUNVIC, Pindamonhangaba, Sa˜o Paulo, Brazil
4
Laborato´rio de Parasitologia, Instituto Ba´sico de Biocieˆncias - IBB, Universidade de Taubate´ - UNITAU, Taubate´, Sa˜o Paulo, Brazil
significantly low toxicity in the concentration of 12.5 lL/ mL when compared to the other species evaluated. Keywords Plant extracts Environmental contamination Ancylostoma spp Toxicity
Introduction Hookworm are the most prevalent parasites in domestic dog (Canis familiaris), and can also trigger pathological processes in humans (Coeˆlho et al. 2013). The occurrence of this parasite is related to environmental contamination, and, in view of this, it becomes necessary to deploy control measures, among which the treatment of infected hosts and the decontamination of the environment, which brings as a disadvantage the possibility of harmful effect to other species of living beings, due to the toxicity of chemical substances used for this purpose (Santos et al. 2013). To get aro
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