Phytogenic products, used as alternatives to antibiotic growth promoters, modify the intestinal microbiota derived from
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GENOMICS, TRANSCRIPTOMICS, PROTEOMICS
Phytogenic products, used as alternatives to antibiotic growth promoters, modify the intestinal microbiota derived from a range of production systems: an in vitro model Yadav S. Bajagai 1 & Jenifer Alsemgeest 1 & Robert J. Moore 2,3 & Thi T. H. Van 2 & Dragana Stanley 1 Received: 18 June 2020 / Revised: 20 October 2020 / Accepted: 2 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The removal of antibiotics from the feeds used in the livestock industry has resulted in the use of a wide range of alternative antimicrobial products that aim to deliver the productivity and health benefits that have traditionally been associated with antibiotics. Amongst the most popular alternatives are phytogenic product-based extracts from herbs and spices with known antimicrobial properties. Despite embracing such alternatives, the industry is still largely unaware of modes of action, their overall effects on animal health, and interactions with other feed additives such as probiotics. To address some of these issues, three phytogenic products were selected and their interactions with caecal microbiota of layers, grown under six different production systems, were investigated in vitro. Caecal microbiotas were grown with and without phytogenic products, and the changes in microbiota composition were monitored by sequencing of 16S rRNA gene amplicons. Phytogenic products and production system both significantly influenced microbiota composition. The three phytogenic products all altered the relative abundance of species within the Lactobacillus genus, by promoting the growth of some and inhibiting other Lactobacillus species. There were also significant alterations in the Bacillus genus. This was further investigated by comparing the effects of the phytogenic products on the growth of a commercially used Bacillus-based probiotic. The phytogens affected the probiotic mix differently, with some promoting the growth of Bacillus sp. at lower phytogenic concentrations, and fully suppressing growth at higher concentrations, indicating the importance of finding an optimal concentration that can control pathogens while promoting beneficial bacteria. Key points • After removal of antibiotics from animal feed, urgent solutions for pathogen control were needed. • Alternative products entered the market without much knowledge on their effects on animal health. • Probiotic products are used in combination with phytogens despite the possible incompatibility. Keywords Microbiota . Chicken . In vitro . Phytobiotic . Bacillus
Introduction Antibiotic growth promoters (AGPs) have been used in the livestock industry since the 1940s discovery that their addition * Dragana Stanley [email protected] 1
Institute for Future Farming Systems, Central Queensland University, Rockhampton, Queensland 4702, Australia
2
School of Science, RMIT University, Bundoora, Victoria 3083, Australia
3
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia
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