Preparation of hollow porous molecularly imprinted and aluminum(III) doped silica nanospheres for extraction of the drug
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ORIGINAL PAPER
Preparation of hollow porous molecularly imprinted and aluminum(III) doped silica nanospheres for extraction of the drugs valsartan and losartan prior to their quantitation by HPLC Habibeh Gholami 1 & Mehrorang Ghaedi 1 & Abbas Ostovan 2 & Maryam Arabi 1
&
Ahmad Reza Bagheri 1
Received: 27 March 2019 / Accepted: 7 September 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2019
Abstract Water compatible hollow porous molecularly imprinted nanospheres (HP-MINs) have been prepared for specific recognition and extraction of the blood pressure regulating drugs valsartan (VAL) and losartan (LOS). All synthetic steps were performed in aqueous medium and without consumption of organic solvents. The morphology and functionality of the materials were characterized by FT-IR, FE-SEM, and TEM techniques. The adsorption and selectivity experiments demonstrate that the HP-MINs possess a high binding capacity, fast kinetics, excellent water dispersibility and remarkable selectivity for VAL and LOS. The HPMINs were utilized for dispersive solid phase extraction of VAL and LOS prior to their determination by HPLC-UV. Main variables and their interactions on extraction yield were optimized by multivariate analysis with least amount of experiments. Under optimized conditions, the method has a linear response in the 5–2000 μg L−1 concentration range of both VAL and LOS. The limits of detection are 1.5 μg L−1 for VAL and 1.4 μg L−1 for LOS. Keywords Molecularly imprinted polymers . Water compatible . Experimental design methodology . Dispersive solid phase extraction . Urine analysis
Introduction Molecularly imprinted polymers (MIPs) are well-known artificial receptors contain specific cavities that are formed in polymer skeleton by considering the memory of the target compound [1]. Remarkable benefits of MIPs viz. facile synthesis routes, rigid structure, physical and chemical stability, cause raise extensive attention to these versatile materials and vast application of them in the various field especially in sample preparation. Happily, MIPs can distinguish analyte of Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-3794-x) contains supplementary material, which is available to authorized users. * Mehrorang Ghaedi [email protected] 1
Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran
2
Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran
interest from interferent compounds in complex matrix and specificity bind with target molecules. Therefore, by employing MIPs as versatile solid phase, the selectivity and sensitivity of the analytical methods can improve significantly [2, 3]. Contrary to unique advantages of MIPs, several challenges including partial template removal, low binding capacity, inadequate mass-transfer of the analyte, and negligible compatibility with aqueous media have been facing that limited their applications. Hence, molecularly imprinted technology (MIT) have been considered as a
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