Rab GTPases Methods and Protocols
This volume covers the latest technological advances in the characterization of the biosynthesis and functions of Rab GTPases and their regulation by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). The book consists of 28
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Guangpu Li Editor
Rab GTPases Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Rab GTPases Methods and Protocols
Edited by
Guangpu Li Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Editor Guangpu Li Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences Center Oklahoma City, OK, USA Peggy and Charles Stephenson Cancer Center University of Oklahoma Health Sciences Center Oklahoma City, OK, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2568-1 ISBN 978-1-4939-2569-8 (eBook) DOI 10.1007/978-1-4939-2569-8 Library of Congress Control Number: 2015934919 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Rab GTPases are master regulators of intracellular membrane trafficking in all eukaryotes from the last eukaryotic common ancestor (LECA) to human. In the human genome, there are 66 Rab genes some of which are ubiquitously expressed in all tissues, while others are expressed only in specific tissues. Individual Rabs target to distinct organelles and vesicles to promote vesicular transport through the exocytic and endocytic pathways, which are fundamental to cell physiology and have great impact on other cellular processes, such as hormone secretion, signal transduction, cell migration, and cell growth/differentiation. Indeed, mutations and/or altered expr
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