Semaphorin Signaling Methods and Protocols
This volume arranged into three sections describes biochemical, in vitro, and in vivo protocols on Semaphorins. Chapters focus on approaches that would allow the novice to study Semaphorins and employ robust assays to characterize mechanisms of action. Wr
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Jonathan R. Terman Editor
Semaphorin Signaling Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Semaphorin Signaling Methods and Protocols
Edited by
Jonathan R. Terman Departments of Neuroscience and Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Editor Jonathan R. Terman Departments of Neuroscience and Pharmacology The University of Texas Southwestern Medical Center Dallas, TX, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6446-8 ISBN 978-1-4939-6448-2 (eBook) DOI 10.1007/978-1-4939-6448-2 Library of Congress Control Number: 2016952542 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Cover image adapted from images in R.J. Hung, C.W. Pak, and J.R. Terman, Science, 334: 1710-1713, 2011. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface There will be signposts of indication, Semaphore ghost signs and warnings Jay Farrar (from the song Medicine Hat by Son Volt)
Originally identified for their role in regulating the shape and guidance of neuronal processes, Semaphorins have now emerged as major players in the formation and maintenance of tissues throughout the body. Indeed, these molecular signals have been aptly named (from the Greek sema meaning sign), since they convey instructions between cells in much the same way that flag semaphore is used to communicate information between people. Since their discovery in 1992, Semaphorins have been the focus of immense interest with over 2500 publications covering a variety of topics on their function and mechanisms of act
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