VEGF Signaling Methods and Protocols
This volume provides a collection of protocols for studying and manipulating VEGF signaling pathways in vitro and in vivo, and in particular, aims to present a range of both firmly established and newly emerging technologies, including those that are amen
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Lorna Fiedler Editor
VEGF Signaling Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
VEGF Signaling Methods and Protocols
Edited by
Lorna Fiedler Caversham, Reading, UK
Editor Lorna Fiedler Caversham Reading, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2916-0 ISBN 978-1-4939-2917-7 (eBook) DOI 10.1007/978-1-4939-2917-7 Library of Congress Control Number: 2015945619 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Since its discovery in the 1980s as a potent endothelial cell growth and permeability inducer, there has been an explosion of research into the role of VEGF (vascular endothelial growth factor or vascular permeability factor) in physiology, pathology, and therapy. VEGF is indispensable for cardiovascular and lymphatic development, and in physiological angiogenesis in the adult (pregnancy, menstruation, and wound healing for example). However its dysregulation underlies multiple diseases including diabetic complications, rheumatoid arthritis, heart failure, hypertension, metastatic cancer, macular degeneration, renal disease, and pre-eclampsia. VEGF and its activators or effectors are therefore particularly attractive therapeutic targets; however more failures than successes have been achieved in clinical translation and it is therefore imperative to understand the cellular mechanisms and consequences involved. This volume provides a collection of protocols for studying and manipulating VEGF signaling pathways in vitro and in vivo, and in particular, ai
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