SUMO Methods and Protocols
This volume explores various methodologies to study biochemical, molecular, and cellular biology aspects of some processes regulated by protein SUMOylation. SUMO: Methods and Protocols is organized into four parts, and starts with an historical overview o
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Manuel S. Rodriguez Editor
SUMO Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
SUMO Methods and Protocols
Edited by
Manuel S. Rodriguez INBIOMED, San Sebastian, Spain
Editor Manuel S. Rodriguez INBIOMED San Sebastian Spain
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6356-0 ISBN 978-1-4939-6358-4 (eBook) DOI 10.1007/978-1-4939-6358-4 Library of Congress Control Number: 2016945171 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Cover illustration: The image depicts a C. elegans embryo in Metaphase of the first mitotic division. Tubulin is seen in green and SUMO in magenta. Image was acquired using 3D structured illumination with an OMX super-resolution microscope. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface The Small Ubiquitin-related MOdifier (SUMO) molecules are implicated in the regulation of multiple critical cellular functions and consequently associated with several pathologies. Functions regulated by the different SUMO molecules are diverse and in most cases unrelated to those controlled by ubiquitin, with the enzymes regulating protein modification and de-modification by SUMO molecules being distinct to those regulating other members of the ubiquitin family. However, recent discoveries indicate that SUMO-regulated functions can be more interconnected with those regulated by ubiquitin than initially suspected. In this volume of SUMO Methods and Protocols, leading experts propose basic and “stateof-the-art” methodologies to explore biochemical, molecular, and cellular biology aspects of some of the many processes regulated by protein SUMOylation. Chapters hig
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