T-Cell Development Methods and Protocols
This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell prepar
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Rémy Bosselut Melanie S. Vacchio Editors
T-Cell Development Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
T-Cell Development Methods and Protocols Edited by
Rémy Bosselut and Melanie S. Vacchio Laboratory of Immune Cell Biology, National Institutes of Health, National Cancer Institute, Bethesda, MD, USA
Editors Rémy Bosselut Laboratory of Immune Cell Biology National Institutes of Health National Cancer Institute Bethesda, MD, USA
Melanie S. Vacchio Laboratory of Immune Cell Biology National Institutes of Health National Cancer Institute Bethesda, MD, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2808-8 ISBN 978-1-4939-2809-5 (eBook) DOI 10.1007/978-1-4939-2809-5 Library of Congress Control Number: 201506151 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Fifty and a few years since the function of the thymus was discovered, the study of T cell development remains a fascinating part of immunology. This is certainly because T cells, essential components of immune responses, develop in the thymus. Interactions in the thymus shape the reactivity and function of T cell precursors and are essential to establish a functional and tolerant immune system. Thus, identifying intrathymic interactions and understanding their mechanisms are intrinsic parts of T cell immunology. In addition, the study of T cell (and more broadly lymphocyte) development has exerted broad appeal beyond the immunological realm. Indeed, throughout their thymic journey, T cell precursors recapi
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