Telomeres and Telomerase Methods and Protocols
This third edition volume expands on the previous editions with new and improved assays that ask essential questions of telomere regulation in diverse model systems. The chapters in this book discuss genetic, proteomic, genomic, biochemical, and molecular
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Zhou Songyang Editor
Telomeres and Telomerase Methods and Protocols Third Edition
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Telomeres and Telomerase Methods and Protocols Third Edition
Edited by
Zhou Songyang Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA
Editor Zhou Songyang Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston, TX, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6891-6 ISBN 978-1-4939-6892-3 (eBook) DOI 10.1007/978-1-4939-6892-3 Library of Congress Control Number: 2017932796 © Springer Science+Business Media LLC 2002, 2011, 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface In 2009, the Nobel Prize in Physiology or Medicine was awarded to Drs. Elizabeth H. Blackburn, Carol W. Greider, and Jack W. Szostak for their pioneering work on telomeres and telomerase, nearly 40 years after the first identification of telomeres. Our knowledge of the telomerase and how telomeres are maintained has continued to grow, thanks in no small part to the ever-expanding tools and platforms that are available to investigators. It is clear that telomere maintenance is critically linked to cell growth, proliferation, aging, and diseases such as cancer. Active investigations are underway to untangle the complex signaling events that lead from telomere dysfunction to premature aging and carcinogenesis. In the second vol
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