The Mitotic Spindle Methods and Protocols
This volume includes a series of protocols focused on mitotic spindle assembly and function. The methods covered in this book feature a broad range of techniques from basic microscopy to the study of spindle physiologies relevant to cancer. These methods
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Paul Chang Ryoma Ohi Editors
The Mitotic Spindle Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
The Mitotic Spindle Methods and Protocols
Edited by
Paul Chang Massachusetts Institute of Technology, Cambridge, MA, USA
Ryoma Ohi Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, USA
Editors Paul Chang Massachusetts Institute of Technology Cambridge, MA, USA
Ryoma Ohi Department of Cell & Developmental Biology Vanderbilt University Nashville, TN, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3540-6 ISBN 978-1-4939-3542-0 (eBook) DOI 10.1007/978-1-4939-3542-0 Library of Congress Control Number: 2016938221 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface The mitotic spindle is a large macromolecular structure that is both beautiful and functionally important. It has long been a focus of intense investigation due to its role as a guardian of ploidy, responsible for the equal segregation of genetic material into daughter cells during cell division. Not surprisingly, the spindle has also been a target of therapeutic inhibition for diseases that involve misregulation of cell division, such as cancer. Indeed, inhibitors of spindle function, such as tubulin poisons, are among the earliest-developed forms of cancer therapy and remain first-line therapies for many forms of cancer. More recently, the spindle has been shown to play equally important roles in other aspects of cell function and human disease. These advances have relied on the development of advanced technology, and as the tools used to
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