The Mitotic Exit Network Methods and Protocols
This detailed book collects the main methodologies used for the analysis of the activity, localization, and regulation of the components of the Mitotic Exit Network (MEN) pathway during mitotic exit in Saccharomyces cerevisiae, as well as for the eva
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Fernando Monje-Casas Ethel Queralt Editors
The Mitotic Exit Network Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
The Mitotic Exit Network Methods and Protocols
Edited by
Fernando Monje-Casas CABIMER, Seville, Spain
Ethel Queralt Cancer Epigenetics & Biology Program, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
Editors Fernando Monje-Casas CABIMER Seville, Spain
Ethel Queralt Cancer Epigenetics & Biology Program IDIBELL Hospitalet de Llobregat, Barcelona, Spain
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6500-7 ISBN 978-1-4939-6502-1 (eBook) DOI 10.1007/978-1-4939-6502-1 Library of Congress Control Number: 2016953126 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The Mitotic Exit Network (MEN) is an essential signaling cascade that promotes mitotic exit, facilitates the control of spindle alignment, and initiates cytokinesis in the budding yeast Saccharomyces cerevisiae. Closely related to the Hippo pathway in mammals and the Septation Initiation Network (SIN) in the fission yeast Schizosaccharomyces pombe, the MEN pathway is activated in mid-late anaphase and triggers exit from mitosis by facilitating the release of the Cdc14 phosphatase and, as a consequence, the inactivation of the global cyclin-dependent kinase (Cdk) activity in the cell. This inactivation of Cdk activity at the end of mitosis is required for the cells to exit from mitosis and enter a new round of cell division. MEN signaling is controlled by the main checkpoints that
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