The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort
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ORIGINAL ARTICLE
The relationship between umbilical cord blood vitamin A levels and late preterm infant morbidities: a prospective cohort study Enfu Tao 1,2 & Caie Chen 2 & Yunqin Chen 2 & Linyan Cai 3 & Tianming Yuan 1,4 Received: 16 May 2020 / Revised: 15 August 2020 / Accepted: 18 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The aim of this study is to explore the association between umbilical cord blood (UCB) vitamin A levels and late preterm infants morbidities. We conducted a prospective cohort study of 208 late-preterm infants(from 34 0/7 to 36 6/7 weeks gestational age) between January 1, 2014 and June 30, 2015. UCB specimens were collected shortly after birth, and vitamin A levels were determined by enzyme-linked immunosorbent assay. Prevalence of low UCB vitamin A level < 0.7 μmol/L was 37.5% in late preterm infants. In comparison to vaginal delivery, cesarean section was associated with UCB vitamin A level < 0.7 μmol/L (P < 0.001). Nevertheless, UCB vitamin A levels did not correlate with gestational age, birth weight, and gender. UCB vitamin A level < 0.7 μmol/L was not an independent risk factor for hospitalization, oxygen supplementation, hyperbilirubinemia, sepsis, and respiratory distress syndrome. Conclusions: Low umbilical cord blood vitamin A levels are common among late-preterm infants. Cesarean section delivery is associated with low umbilical cord blood vitamin A level. Low umbilical cord blood vitamin A levels at birth do not increase morbidity of late-preterm infants, including hyperbilirubinemia, sepsis, and respiratory distress syndrome. What is Known: • Late preterm infants have a higher morbidity and mortality rates when compared to term infants. • Low plasma vitamin A levels increase the risk of preterm infants’ morbidity. What is New: • Late preterm infants commonly have low level of umbilical cord blood vitamin A. • Low umbilical cord blood vitamin A level at birth appears to be not associated with the morbidity of late-preterm infants. • Cesarean section is associated with low umbilical cord blood vitamin A level < 0.7 μmol/L compared with vaginal delivery.
Keywords Umbilical cord blood . Vitamin A . Late-preterm infant . Respiratory distress syndrome . Hyperbilirubinemia
Communicated by: Daniele De Luca Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00431-020-03787-1) contains supplementary material, which is available to authorized users. * Tianming Yuan [email protected]
1
Enfu Tao [email protected]
Department of Neonatology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
2
Caie Chen [email protected]
Department of Neonatology, Wenling Maternal and Child Health Care Hospital, Wenling, Zhejiang Province, China
3
Yunqin Chen [email protected]
Department of Obstetrics and Gynecology, Wenling Maternal and Child Health Care Hospital, Wenling, Zhejiang Province, China
4
Children’s Hospital, Zhejiang Un
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