Thermogenic Fat Methods and Protocols
This volume presents a collection of protocols that describe methodologies to study thermogenic fat biology from various angles. This book is divided into 2 parts. Part 1 focuses on establishing in vitro culture systems. The chapters in this section intro
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Jun Wu Editor
Thermogenic Fat Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Thermogenic Fat Methods and Protocols
Edited by
Jun Wu Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
Editor Jun Wu Department of Molecular and Integrative Physiology, Life Sciences Institute University of Michigan Ann Arbor, MI, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6819-0 ISBN 978-1-4939-6820-6 (eBook) DOI 10.1007/978-1-4939-6820-6 Library of Congress Control Number: 2017932076 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The rediscovery of thermogenic adipocytes in human adults has reignited a great deal of enthusiasm towards these unique metabolic cells that convert chemical energy into heat, therefore holding great promise for helping to counteract obesity and its associated metabolic disorders. It is now appreciated that at least two types of thermogenic adipocytes exist in rodents and humans, classical brown and inducible beige adipocytes. These two types of fat cells arise from distinct developmental origins and position in different anatomical locations. In contrast to white adipocytes that store surplus energy, brown and beige fat cells dissipate chemical energy through uncoupling protein 1 (UCP1), together with other mechanisms. In addition to their respective r
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