A gold electrode modified with a gold-graphene oxide nanocomposite for non-enzymatic sensing of glucose at near-neutral
- PDF / 1,591,184 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 75 Downloads / 174 Views
ORIGINAL PAPER
A gold electrode modified with a gold-graphene oxide nanocomposite for non-enzymatic sensing of glucose at near-neutral pH values Chaohui He 1 & Jiakai Wang 1 & Nan Gao 1 & Hanping He 2 & Kailun Zou 1 & Mingyu Ma 1 & Yang Zhou 1 & Zhiwei Cai 1 & Gang Chang 1 & Yunbin He 1 Received: 28 March 2019 / Accepted: 7 September 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2019
Abstract A nanocomposite was prepared from gold and graphene oxide via one-step electrodeposition and used to modify the surface of a gold electrode (Au-Gr/GE) that was then applied to non-enzymatic determination of glucose. The effects of deposition time and supporting substrate on the morphology, structure, and electrochemical properties of the nanocomposite were optimized. The morphologies and crystal structures were characterized by scanning electron microscopy, transmission electron microscopy, and X-ray diffraction. The results indicate that gold nanoparticles grew on the surface of two-dimensional graphene oxide. The electrocatalytic activity of the modified electrode towards glucose oxidation was evaluated by cyclic voltammetry and amperometric methods at pH 7.4. The Au-Gr/GE, typically operated at a potential of 0.00 V (vs. Ag/AgCl), has a linear response in the 0.05–14 mM and 14–42 mM glucose concentration range, high sensitivity (604 and 267 μA cm−2 mM−1) and a low detection limit (12 μM). The modified GE was applied to quantify glucose in sweat where it exhibited excellent sensitivity and accuracy. Keywords Glucose detection . Non-invasive . One-step electrodeposition . Sweat . High sensitivity . Selectivity
Introduction The accurate monitoring of blood glucose levels is critical for the prevention and treatment of diabetes [1, 2]. In the past few decades, the majority of research has focused on the traditionElectronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-3796-8) contains supplementary material, which is available to authorized users. * Gang Chang [email protected] * Yunbin He [email protected] 1
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, No.368 Youyi Avenue, Wuchang, Wuhan 430062, China
2
Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineer, Hubei University, Youyi Road 368, Wuchang, Wuhan 430062, Hubei, China
al glucose sensors which rely on the catalysis of glucose oxidase on glucose. Although these enzyme-based sensors display good performance in detecting glucose, their instability, being susceptible vulnerability to temperature and interfering chemicals, limits their further development. Non-enzymatic glucose biosensors exhibit higher stability than the enzymebased glucose biosensor, mainly because in the nonenzymatic biosensors the glucose can directly generate current signals on
Data Loading...
