Ultra-sensitive amperometric determination of quercetin by using a glassy carbon electrode modified with a nanocomposite
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ORIGINAL PAPER
Ultra-sensitive amperometric determination of quercetin by using a glassy carbon electrode modified with a nanocomposite prepared from aminated graphene quantum dots, thiolated β-cyclodextrin and gold nanoparticles Zhidu Zhou 1 & Pengcheng Zhao 1 & Chenxi Wang 1 & Pingping Yang 1 & Yixi Xie 1,2
&
Junjie Fei 1,3
Received: 5 September 2019 / Accepted: 30 December 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Thiolated β-cyclodextrin functionalized gold nanoparticles (Au-β-CDs) with layered wrinkled flower structure were prepared. Au-β-CDs were electrostatically combined with protonated aminated graphene quantum dots (NH2-GQDs) to form a nanocomposite with better supramolecular recognition, conductivity, catalysis and dispersion properties. For constructing a quercetin (QU) sensor, the nanocomposites were one-step electrodeposited by a cyclic voltammetry (CV) method onto a glassy carbon electrode to form a stable film. Under optimized conditions, the sensor showed a wide linear response range of 1–210 nM, with a lower detection limit of 285 pM. At the same time, flavonoids with similar structures hardly interfere with the determination of QU. The sensor has been used to determine QU in honey, tea, honeysuckle and human serum with satisfactory results.
Keywords Electrodeposition . Differential pulse voltammetry . Aminated graphene quantum dots . Thiolated β-cyclodextrin . AuNPs . Quercetin . Supramolecular recognition . Electrochemical sensor
Introduction
Zhidu Zhou and Pengcheng Zhao contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-4106-1) contains supplementary material, which is available to authorized users. * Yixi Xie [email protected] * Junjie Fei [email protected] 1
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, People’s Republic of China
2
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Xiangtan University, Xiangtan 411105, People’s Republic of China
3
Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiangtan 411105, People’s Republic of China
Querceton (QU; 3,3′,4′,5,7-pentahydroxyflavone) is one of the most common flavonoids in the human diet. It is widely found in Chinese herbal medicines, beverages, fruits and vegetables, and provides protection for body health [1]. A recent study showed that quercetin can kill aging cells, significantly prolonging animal life and reducing aging symptoms [2, 3]. However, an overdosage of QU may lead to kidney cancer [4]. Therefore, it is necessary to accurately detect QU, which is useful for evaluating the antioxidant activity of QU in pharmacology and the nutritional quality in food chemistry. Chromatographic [5], spectrophotometric [6, 7] and capillary electrophoresis [8, 9] methods are commonly used in the accurate determination of QU concentratio
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