Chromosome Architecture Methods and Protocols
This volume details a valuable collection of protocols and reviews, such as emerging experimental and theoretical approaches. These approaches have resulted in a substantial improvement in the understanding of chromosome architecture. Chromosome Arch
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Mark C. Leake Editor
Chromosome Architecture Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Chromosome Architecture Methods and Protocols
Edited by
Mark C. Leake Biological Physical Sciences Institute, University of York, Heslington, York, UK
Editor Mark C. Leake Biological Physical Sciences Institute University of York Heslington, York, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3629-8 ISBN 978-1-4939-3631-1 (eBook) DOI 10.1007/978-1-4939-3631-1 Library of Congress Control Number: 2016937009 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Traditional insight into the composition, and functional properties, of chromosomes has stemmed largely either from conventional bulk ensemble average techniques in vitro or from optical microscopy methods on either fixed cell samples or living cells, but restricted to standard optical resolution limits. However, over the past few years several cutting-edge interdisciplinary methods have emerged which now enable us to understand the architecture of chromosomes with exceptionally enhanced resolution, both in terms of space and time; in other words, to probe the dynamic architecture of chromosomes, and at a molecular length scale of precision. These emerging interdisciplinary tools have grown in particular from biophysics, including several single-molecule methods and super-resolution techniques. This volume of Chromosome Architecture includes a valuable new collection of protocols and reviews of such emerging experimental and theoretical approaches, which have resulted in a substan
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