Dexamethasone
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Overlap Stevens-Johnson syndrome/toxic epidermal necrolysis: case report A 65-year-old man developed overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) during treatment with dexamethasone for ductal carcinoma of the breast. The man presented with 12h history of deteriorating rash. He reported feeling severely unwell. Two weeks prior to the presentation, he had completed a course of neoadjuvant chemotherapy that comprised of docetaxel, carboplatin and trastuzumab. Other intermittently received drugs included dexamethasone [dosage and route not stated] and domperidone. Examinations, showed bullae, widespread atypical targetoid lesions and 15% epidermal detachment. Mucosal involvement was not noted at the time of presentation, which developed later. Skin biopsy showed subepidermal blistering with epidermal necrosis. Based on the examinations, a clinical diagnosis of overlap SJS/TEN was made [duration of treatment to reaction onset not stated]. His Score of Toxic Epidermal Necrosis (SCORTEN) was noted as 4 with a projected mortality rate of 58%. Subsequently, he was shifted to ICU, and his treatment was started by a multidisciplinary team [outcome not stated]. O’Reilly P, et al. The psychological impact of Stevens-Johnson syndrome and toxic epidermal necrolysis on patients' lives: a Critically Appraised Topic. British Journal 803504690 of Dermatology 183: 452-461, No. 3, Sep 2020. Available from: URL: http://doi.org/10.1111/bjd.18746
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Reactions 3 Oct 2020 No. 1824
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