Dexamethasone
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Adrenal insufficiency following rapid tapering: case report In a retrospective single-centre study involving 25 patietns who underwent craniotomies for cerebral radiation necrosis between 2011 and 2016, a 67-year-old woman was described, who developed adrenal insufficiency following a rapid tapering of dexamethasone for the treatment of radiation necrosis. The woman with unspecified metastatic brain tumour, started receiving stereotactic radiosurgery. Subsequently, she developed histopathologically confirmed cerebral radiation necrosis. Initially, it was conservatively managed with a short course of dexamethasone [route and dosage not stated]. However, as the radiation necrosis was refractory to the treatment, she was scheduled to undergo craniotomy as the location of radiation necrosis was surgically accessible. Following the procedure, the dexamethasone dose was rapidly tapered (drug withdrawal), which led to the development of adrenal insufficiency [outcome not stated]. At 16.48 months after the procedure, she died [immediate cause of death not stated]. Shah AH, et al. Salvage craniotomy for treatment-refractory symptomatic cerebral radiation necrosis. Neuro-Oncology Practice 7: 94-102, No. 1, Feb 2020. Available from: 803501967 URL: http://doi.org/10.1093/nop/npz028
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Reactions 19 Sep 2020 No. 1822
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