Dexamethasone
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Cushing’s syndrome, skin disorders, hypertension and weight gain in a child: case report A 9-year-old boy started receiving dexamethasone 4mg three times daily [route not stated] for cerebral oedema secondary to radiation necrosis. His neurological function recovered, but cerebral oedema recurred when his dexamethasone dosage was decreased below 1mg three times daily. He ultimately reported experiencing unacceptable side effects such as iatrogenic Cushing’s syndrome, arterial hypertension, skin ulcerations, distended striae and an increased in body mass index (from 17 to 26 kg/m2)[duration of treatment to reaction onsets not stated]. He then began receiving a 16-week bevacizumab trial, during which dexamethasone was discontinued [outcomes not stated]. Merkenschlager A, et al. Successful bevacizumab therapy for CNS radiation necrosis after stereotactic radiotherapy of an arteriovenous malformation. Neuropediatrics 42: Mar 2011. Available from: URL: http://dx.doi.org/10.1055/ 803069204 s-0031-1274018 [abstract] - Germany
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Reactions 14 Apr 2012 No. 1397
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