Immunotoxicity Testing Methods and Protocols
This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identif
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Jamie C. DeWitt Cheryl E. Rockwell Christal C. Bowman Editors
Immunotoxicity Testing Methods and Protocols Second Edition
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Immunotoxicity Testing Methods and Protocols Second Edition
Edited by
Jamie C. DeWitt Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC, USA
Cheryl E. Rockwell Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
Christal C. Bowman Durham, NC, USA
Editors Jamie C. DeWitt Department of Pharmacology and Toxicology East Carolina University Greenville, NC, USA
Cheryl E. Rockwell Department of Pharmacology and Toxicology Michigan State University East Lansing, MI, USA
Christal C. Bowman Durham, NC, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-8548-7 ISBN 978-1-4939-8549-4 (eBook) https://doi.org/10.1007/978-1-4939-8549-4 Library of Congress Control Number: 2018942539 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface to the First Edition Immunotoxicology as an interdisciplinary area of research, assessment, and instruction has been formally recognized since at least the 1970s. The science supporting i mmunotoxicology has driven both mechanistic research defining the interactions between xenobiotics and the immune system as well as safety testing for chemicals, drugs, and
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