Immunotoxicity Testing Methods and Protocols

Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these ch

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Molecular Biology™

Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK



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Immunotoxicity Testing Methods and Protocols

Edited by

Rodney R. Dietert Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA

Editor Rodney R. Dietert Department of Microbiology and Immunology College of Veterinary Medicine Cornell University Ithaca, NY 14853 USA [email protected]

ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-400-5 e-ISBN 978-1-60761-401-2 DOI 10.1007/978-1-60761-401-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009936794 © Humana Press, a part of Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or ­dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, ­neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

Preface Immunotoxicology as an interdisciplinary area of research, assessment, and instruction has been formally recognized since at least the 1970s. The science supporting immunotoxicology has driven both mechanistic research defining the interactions between xenobiotics and the immune system as well as safety testing for chemicals, drugs, and medical devices. During that time, there have emerged societies, specialty sections, and entire journals devoted solely to Immunotoxicology. While several important books have been prepared on this and related topics, Immunotoxicity Testing is among the first to meld consideration of immunotoxicity testing approaches and strategies with a comprehensive presentation of detailed laboratory protocols. The goal of the book is to utilize the expertise of scientists actually engaged in immunotoxocity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. The book includes an introduction to