Metabonomics Methods and Protocols
This volume on metabonomics provides detailed information on the procedures involved in nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LC-MS), and capillary electrophor
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Jacob T. Bjerrum Editor
Metabonomics Methods and Protocols
METHODS
IN
M O L E C U L A R B I O LO G Y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Metabonomics Methods and Protocols
Edited by
Jacob T. Bjerrum Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Editor Jacob T. Bjerrum Department of Gastroenterology Medical Section, Herlev Hospital University of Copenhagen Copenhagen, Denmark
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2376-2 ISBN 978-1-4939-2377-9 (eBook) DOI 10.1007/978-1-4939-2377-9 Library of Congress Control Number: 2015931074 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Metabonomics is the comprehensive study of metabolic changes in an integrated biological system and has become a vital tool in research areas such as biomarker discovery, diagnostics, drug development, and toxicology. However, both endogenous and exogenous metabolites constitute the complete human metabolome making a comprehensive characterization extremely difficult especially, as the metabolome is an ever-changing and exceptionally dynamic structure due to the continuous influence of both the environment and “in”vironment. This has, however, not stopped the field of metabonomics research from trying to untangle the human metabolic web with the use of ongoing technical advancements in the field combined with the invaluable chemometrics. Without any prior knowledge, it can be an overwhelming task to get an overview of and insight into the field of metabonomics.
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