Oligodendrocytes Methods and Protocols
This volume looks at the study of oligodendrocytes through in vitro and in vivo techniques, multiple model organisms, using approaches that bridge scales from molecular through system. Chapters in this book cover topics such as fundamental molecular analy
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David A. Lyons Linde Kegel Editors
Oligodendrocytes Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Oligodendrocytes Methods and Protocols
Edited by
David A. Lyons and Linde Kegel Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
Editors David A. Lyons Centre for Discovery Brain Sciences University of Edinburgh Edinburgh, UK
Linde Kegel Centre for Discovery Brain Sciences University of Edinburgh Edinburgh, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9070-2 ISBN 978-1-4939-9072-6 (eBook) https://doi.org/10.1007/978-1-4939-9072-6 Library of Congress Control Number: 2019930142 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover Caption: Single oligodendrocyte, labelled with GFP in a transgenic zebrafish. Image courtesy of Dr. Rafael Almeida, Lyons Lab, University of Edinburgh, Edinburgh, UK. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface We have known for nearly a century that the oligodendrocyte is the glial cell of the central nervous system that generates myelin. Similarly, we have known for decades that the presence of myelin on axons speeds up conduction velocities, by virtue of the fact that myelin sequesters key ion channels to the short nodes of Ranvier between consecutive myelin sheaths and due to the remarkable properties of the lipid-rich myelin sheath itself. The myelination of axons allows rapid information propagation throughout specifi
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